How to Take Care of Your Gut After Doxy-PEP: 5 Smart Tips

Doxy-PEP is a game-changer in STI prevention—and it’s becoming a common and effective tool in many gay men’s health routines. But let’s be real: antibiotics like doxycycline can throw your gut microbiome out of balance, leading to bloating, gas, loose stools, or just not feeling great.

Here are 5 easy, science-backed ways to support your gut after taking doxy-PEP:

1. Eat Fermented Foods (Yes, That Means Kimchi and Yogurt)

Antibiotics kill off both harmful and beneficial bacteria. Fermented foods like kimchi, sauerkraut, miso, tempeh, kefir, and unsweetened yogurt can help restore some of that good gut flora. Aim for a small daily serving after your doxy dose finishes.

2. Take a Quality Probiotic (But Time It Right)

A broad-spectrum probiotic with strains like Lactobacillus and Bifidobacterium may help repopulate your gut. Wait until you've finished your doxy-PEP course before starting a probiotic, as the antibiotic may otherwise kill off the helpful bacteria.

3. Go Fiber-Forward

Prebiotic fibers feed the good bacteria you want to grow. Load up on fruits (like bananas and apples), veggies (like onions, garlic, and artichokes), and whole grains. Just go slow—too much fiber too fast can be, well, explosive.

4. Hydrate Like It’s Your Job

Doxy can cause mild dehydration and loose stools, especially if it irritates your stomach. Hydration helps keep everything moving and supports overall gut function. Add a pinch of sea salt or an electrolyte mix if you're feeling off.

5. Rest and Reset

Stress messes with your gut, too. Even a few days of disrupted sleep or high stress can throw your microbiome off. After antibiotics, take it as an invitation to rest, sleep, and let your body recalibrate.

Your gut deserves love, too.
Taking doxy-PEP is a proactive, smart move—but so is tending to the rest of your health. A little extra care now means feeling better, digesting better, and staying strong for whatever’s next.

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